PART STUDY
Part Study
Name of Project: Paediatric Anti-Retroviral Therapy (PART) study
Overall Principal Investigator: Dr. William Moss / Dr. Katie Sutcliffe
Local PI: Dr. Philimon Ndubani and MR Nkumbula Moyo
Local Study Coordinator: Mr. Francis Hamangaba
Overall Principal Investigator: Dr. William Moss / Dr. Katie Sutcliffe
Local PI: Dr. Philimon Ndubani and MR Nkumbula Moyo
Local Study Coordinator: Mr. Francis Hamangaba
This longitudinal cohort study of children infected with HIV has been running since September-2007. The basic aim is to determine the factors that affect the outcome of these children; with 4 aims. The fourth aim was added as an amendment to include a new sub-study “Food and Water Insecurity Study (F&WI Study)”.
Aim 1: Measure immunologic and virologic treatment responses and survival in a cohort of HIV-1 infected children and adolescents receiving ART at Macha Hospital in rural Zambia.
Aim 2: Identify risk factors for antiretroviral treatment failure and death in children and adolescents residing in rural Zambia and cared for at Macha Hospital, including antiretroviral drug resistance, obstacles to adherence, barriers to care the health status of the child’s primary caregiver, and household food and water insecurity.
Aim 3: Measure the rate of disease progression in HIV-1-infected children and adolescents who are not eligible for ART to evaluate treatment guidelines on when to initiate ART in rural Zambia.
Aim 4: Identify coping mechanisms and entry points for future interventions among a subset of household of children living with HIV experiencing food or water insecurity
Aim 2: Identify risk factors for antiretroviral treatment failure and death in children and adolescents residing in rural Zambia and cared for at Macha Hospital, including antiretroviral drug resistance, obstacles to adherence, barriers to care the health status of the child’s primary caregiver, and household food and water insecurity.
Aim 3: Measure the rate of disease progression in HIV-1-infected children and adolescents who are not eligible for ART to evaluate treatment guidelines on when to initiate ART in rural Zambia.
Aim 4: Identify coping mechanisms and entry points for future interventions among a subset of household of children living with HIV experiencing food or water insecurity
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Macha Research Trust, Choma, Macha , Southern 10101, Zambia
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